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Effects of Microcystis on Hypothalamic-Pituitary-Gonadal-Liver Axis in Nile Tilapia (Oreochromis niloticus)

Authors
  • Chen, Jiazhang1, 2
  • Meng, Shunlong1, 2
  • Xu, Hai3
  • Zhang, Zhen3
  • Wu, Xiangyang3
  • 1 Chinese Academy of Fishery Sciences, Freshwater Fisheries Research Center, Wuxi, 214081, China , Wuxi (China)
  • 2 CAFS, Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, Wuxi, 214081, China , Wuxi (China)
  • 3 Jiangsu University, School of Environment and Safety Engineering, Zhenjiang, 212013, China , Zhenjiang (China)
Type
Published Article
Journal
Bulletin of Environmental Contamination and Toxicology
Publisher
Springer-Verlag
Publication Date
Feb 24, 2017
Volume
98
Issue
4
Pages
562–566
Identifiers
DOI: 10.1007/s00128-017-2051-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

In the present study, Nile tilapia (Oreochromis niloticus) were used to assess the endocrine disruption potential of Microcytis aeruginosa. Male Nile tilapia were exposed to lyophilized M. aeruginosa or purified microcystin-LR (8.3 μg/L) for 28 days. The levels of serum hormones (17β-estradiol and testosterone) and transcripts of selected genes in the hypothalamus-pituitary-gonadal-liver axis were analyzed. The results showed that serum hormones were significantly up-regulated, and transcripts of 13 genes (GHRH, PACAP, GH, GHR1, GHR2, IGF1, IGF2, CYP19a, CYP19b, 3β-HSD1, 20β-HSD, 17β-HSD1 and 17β-HSD8) were significantly altered after Microcytis exposure. These results indicate that fish reproduction can be altered in a Microcystis bloom-contaminated aquatic environment.

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