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Effects of metkephamid (LY127623), a selective delta opioid receptor agonist, on gastric function.

Authors
  • Glavin, G B
  • Pinsky, C
  • Hall, A M
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Jan 01, 1990
Volume
46
Issue
15
Pages
1075–1079
Identifiers
PMID: 2159095
Source
Medline
License
Unknown

Abstract

Metkephamid, a delta opioid receptor agonist, blocked cold-restraint stress ulcers, reduced absolute ethanol-induced gastric ulcers and, at the lowest and highest doses examined, reduced basal gastric acid secretion in conscious rats, all to a significant degree. The dose effects on stress ulcer formation parallel those seen against maximal electroshock seizures and suggest that both central as well as peripheral delta opioid receptors mediate gastrointestinal responses to stress.

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