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Effects of mating on progesterone receptor isoforms in rat hypothalamus.

Authors
  • Mendoza-Garcés, Luciano
  • Camacho-Arroyo, Ignacio
  • Cerbón, Marco A
Type
Published Article
Journal
Neuroreport
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
May 12, 2010
Volume
21
Issue
7
Pages
513–516
Identifiers
DOI: 10.1097/WNR.0b013e3283390440
PMID: 20375746
Source
Medline
License
Unknown

Abstract

In rodents, the display of sexual behavior during proestrus-estrus transition depends on the effect of estradiol and progesterone. Progesterone exerts its effects through intracellular receptor (PR) of which two isoforms (PR-A and PR-B) are found, with different regulation and function. In this study the effects of mating on the expression pattern of PR isoforms in the hypothalamus were investigated during proestrus-estrus transition by using western blot. PR-B isoform content significantly diminished during proestrus-estrus transition both in mated and nonmated female rats. In contrast, PR-A isoform content significantly increases during this period in nonmated rats, whereas it does not change in mated animals. These data show that PR isoforms are differentially expressed throughout proestrus-estrus transition and that mating modifies PR isoforms expression in the hypothalamus of the rat.

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