Affordable Access

deepdyve-link
Publisher Website

Effects of maternal dietary supplementation of phytosterol esters during gestation on muscle development of offspring in mice.

Authors
  • Zhao, Weijie1
  • Su, Han1
  • Wang, Leshan1
  • Sun, Lijuan1
  • Luo, Pei1
  • Li, Yongxiang1
  • Wu, Hanyu1
  • Shu, Gang1
  • Wang, Songbo1
  • Gao, Ping1
  • Zhu, Xiaotong1
  • Jiang, Qingyan2
  • Wang, Lina3
  • 1 Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510640, Guangdong, People's Republic of China. , (China)
  • 2 Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510640, Guangdong, People's Republic of China; National Engineering Research Center for the Breeding Swine Industry, South China Agricultural University, Guangzhou, 510640, Guangdong, People's Republic of China. Electronic address: [email protected] , (China)
  • 3 Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510640, Guangdong, People's Republic of China; National Engineering Research Center for the Breeding Swine Industry, South China Agricultural University, Guangzhou, 510640, Guangdong, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier
Publication Date
Dec 03, 2019
Volume
520
Issue
2
Pages
479–485
Identifiers
DOI: 10.1016/j.bbrc.2019.10.056
PMID: 31607479
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The development of muscle in the embryo, which is crucial for postnatal skeletal muscle growth, has been investigated widely. Much has been learned during the past several decades about the role of maternal nutrition in the outcome of pregnancy. Protein and carbohydrate levels during pregnancy have been shown to be important in the development of offspring, especially muscle development. However, the maternal effects of steroids were still not clear. Phytosterol esters (PEs) are produced by the esterification of phytosterols and fatty acids and have many beneficial functions, such as anti-inflammation and hypolipemic functions. Through the effect of regulation on lipid metabolism, can pregnant mice fed with PEs show any programming effect on the muscle development of offspring? In our study, PEs were supplied to the maternal diet, and changes in maternal lipid metabolism and the development of offspring skeletal muscle were detected. As a result, the amniotic fluid total bile acid (TBA) and total cholesterol (TC) levels were decreased; the growth of offspring was significantly faster than that of the control group until 6 weeks of age. Adult offspring had a higher lean mass index and grip strength. In skeletal muscle, the proportion of myosin heavy chain (MHC) 1 was significantly decreased, while the proportion of MHC 2 b was increased. In conclusion, maternal PEs significantly reduced sterols in the amniotic fluid, while skeletal muscle development was promoted in the offspring. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times