Affordable Access

deepdyve-link
Publisher Website

Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection

Authors
  • Nishi, Akinori1
  • Kaifuchi, Noriko1
  • Shimobori, Chika1
  • Ohbuchi, Katsuya1
  • Iizuka, Seiichi1
  • Sugiyama, Aiko1
  • Ogura, Keisuke1
  • Yamamoto, Masahiro1
  • Kuroki, Haruo2
  • Nabeshima, Shigeki3
  • Yachie, Ayako4
  • Matsuoka, Yukiko4
  • Kitano, Hiroaki4
  • 1 Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, Japan
  • 2 Sotobo Children’s Clinic, Medical Corporation Shigyo-No-Kai, Isumi, Chiba Japan
  • 3 Fukuoka University Hospital,
  • 4 The Systems Biology Institute,
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Feb 19, 2021
Volume
11
Identifiers
DOI: 10.1038/s41598-021-82707-1
PMID: 33608574
PMCID: PMC7896050
Source
PubMed Central
Keywords
License
Unknown

Abstract

Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.

Report this publication

Statistics

Seen <100 times