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Effects of a malfunctional column on conventional and FeedCol-simulated moving bed chromatography performance.

Authors
  • Song, Ji-Yeon1
  • Oh, Donghoon1
  • Lee, Chang-Ha2
  • 1 Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, South Korea. , (North Korea)
  • 2 Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, South Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Jul 17, 2015
Volume
1403
Pages
104–117
Identifiers
DOI: 10.1016/j.chroma.2015.05.034
PMID: 26037316
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The effects of a malfunctional column on the performance of a simulated moving bed (SMB) process were studied experimentally and theoretically. The experimental results of conventional four-zone SMB (2-2-2-2 configuration) and FeedCol operation (2-2-2-2 configuration with one feed column) with one malfunctional column were compared with simulation results of the corresponding SMB processes with a normal column configuration. The malfunctional column in SMB processes significantly deteriorated raffinate purity. However, the extract purity was equivalent or slightly improved compared with the corresponding normal SMB operation because the complete separation zone of the malfunctional column moved to a lower flow rate range in zones II and III. With the malfunctional column configuration, FeedCol operation gave better experimental performance (up to 7%) than conventional SMB operation because controlling product purity with FeedCol operation was more flexible through the use of two additional operating variables, injection time and injection length. Thus, compared with conventional SMB separation, extract with equivalent or slightly better purity could be produced from FeedCol operation even with a malfunctional column, while minimizing the decrease in raffinate purity (less than 2%). Copyright © 2015 Elsevier B.V. All rights reserved.

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