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Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells.

Authors
  • Oda, H
  • Kasiske, B L
  • O'Donnell, M P
  • Keane, W F
Type
Published Article
Journal
Kidney international. Supplement
Publication Date
Jul 01, 1999
Volume
71
Identifiers
PMID: 10412776
Source
Medline
License
Unknown

Abstract

PDGF-BB induces cyclins D1 and E prior to the onset of DNA synthesis in VSMCs. Lovastatin may suppress DNA synthesis in VSMCs by inducing p27Kip1 and reducing expression of cyclins D1 and E.

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