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Distinct Impact of Natural Sugars from Fruit Juices and Added Sugars on Caloric Intake, Body Weight, Glycaemia, Oxidative Stress and Glycation in Diabetic Rats.

Authors
  • Monteiro-Alfredo, Tamaeh1, 2, 3, 4
  • Caramelo, Beatriz1, 2, 3
  • Arbeláez, Daniela1
  • Amaro, Andreia1, 2, 3
  • Barra, Cátia1, 2, 3, 5
  • Silva, Daniela1, 2, 3
  • Oliveira, Sara1, 2, 3
  • Seiça, Raquel1
  • Matafome, Paulo1, 2, 3, 6
  • 1 Coimbra Institute of Clinical and Biomedical Research (iCBR) and Institute of Physiology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. , (Portugal)
  • 2 Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal. , (Portugal)
  • 3 Clinical Academic Center of Coimbra, 3000-548 Coimbra, Portugal. , (Portugal)
  • 4 Research Group of Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados 79825-070, MS, Brazil. , (Brazil)
  • 5 Universitary Hospital Center of Coimbra, 3000-548 Coimbra, Portugal. , (Portugal)
  • 6 Department of Complementary Sciences, Instituto Politécnico de Coimbra, Coimbra Health School (ESTeSC), 3046-854 Coimbra, Portugal. , (Portugal)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Aug 25, 2021
Volume
13
Issue
9
Identifiers
DOI: 10.3390/nu13092956
PMID: 34578832
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although fruit juices are a natural source of sugars, there is a controversy whether their sugar content has similar harmful effects as beverages' added-sugars. We aimed to study the role of fruit juice sugars in inducing overweight, hyperglycaemia, glycation and oxidative stress in normal and diabetic animal models. In diabetic Goto-Kakizaki (GK) rats, we compared the effects of four different fruit juices (4-weeks) with sugary solutions having a similar sugar profile and concentration. In vitro, the sugary solutions were more susceptible to AGE formation than fruit juices, also causing higher postprandial glycaemia and lower erythrocytes' antioxidant capacity in vivo (single intake). In GK rats, ad libitum fruit juice consumption (4-weeks) did not change body weight, glycaemia, oxidative stress nor glycation. Consumption of a matched volume of sugary solutions aggravated fasting glycaemia but had a moderate impact on caloric intake and oxidative stress/glycation markers in tissues of diabetic rats. Ad libitum availability of the same sugary solutions impaired energy balance regulation, leading to higher caloric intake than ad libitum fruit juices and controls, as well as weight gain, fasting hyperglycaemia, insulin intolerance and impaired oxidative stress/glycation markers in several tissues. We demonstrated the distinct role of sugars naturally present in fruit juices and added sugars in energy balance regulation, impairing oxidative stress, glycation and glucose metabolism in an animal model of type 2 diabetes.

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