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Effects of long-term administration of recombinant bovine tumor necrosis factor-alpha on glucose metabolism and growth hormone secretion in steers.

Authors
  • Kushibiki, S
  • Hodate, K
  • Shingu, H
  • Ueda, Y
  • Mori, Y
  • Itoh, T
  • Yokomizo, Y
Type
Published Article
Journal
American Journal of Veterinary Research
Publisher
American Veterinary Medical Association
Publication Date
May 01, 2001
Volume
62
Issue
5
Pages
794–798
Identifiers
PMID: 11341406
Source
Medline
License
Unknown

Abstract

Prolonged treatment with rbTNF induced insulin resistance and inhibited GHRH-stimulated release of GH in steers. Results indicate that rbTNF is a proximal mediator of insulin resistance and inhibits release of GH during periods of endotoxemia or infection.

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