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Effects of Lenvatinib on Skeletal Muscle Volume and Cardiac Function in Patients with Hepatocellular Carcinoma

Authors
  • Nagai, Hidenari
  • Amanuma, Makoto
  • Mukozu, Takanori
  • Kobayashi, Kojiro
  • Nagumo, Hideki
  • Mohri, Kunihide
  • Watanabe, Go
  • Yoshimine, Naoyuki
  • Ogino, Yu
  • Daido, Yasuko
  • Matsukiyo, Yasushi
  • Matsui, Teppei
  • Wakui, Noritaka
  • Momiyama, Koichi
  • Higai, Koji
  • Matsuda, Takahisa
  • Igarashi, Yoshinori
Type
Published Article
Journal
Oncology
Publisher
S. Karger AG
Publication Date
Jun 26, 2023
Volume
101
Issue
10
Pages
634–644
Identifiers
DOI: 10.1159/000531562
PMID: 37364546
Source
Karger
Keywords
Disciplines
  • Clinical Study
License
Green
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Abstract

Introduction: Previously, we reported that the tyrosine kinase inhibitor (TKI) sorafenib decreases serum levels of carnitine and reduces skeletal muscle volume. Moreover, others reported that TKIs might lead to cardiomyopathy or heart failure. Therefore, this study aimed to evaluate the effects of lenvatinib (LEN) on skeletal muscle volume and cardiac function in patients with hepatocellular carcinoma (HCC). Methods: This retrospective study included 58 adult Japanese patients with chronic liver diseases and HCC treated with LEN. Blood samples were collected before and after 4 weeks of treatment, and serum carnitine fraction and myostatin levels were measured. Before and after 4–6 weeks of treatment, the skeletal muscle index (SMI) was evaluated from computed tomography images and cardiac function was assessed by ultrasound cardiography. Results: After treatment, SMI, serum levels of total carnitine, and global longitudinal strain were significantly lower, but serum levels of myostatin were significantly higher. Left ventricular ejection fraction showed no significant change. Conclusion: In patients with HCC, LEN decreases serum levels of carnitine, skeletal muscle volume, and worsens cardiac function.

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