Affordable Access

Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats.

Authors
  • Finnegan, K T
  • Calder, L
  • Clikeman, J
  • Wei, S
  • Karler, R
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Feb 12, 1993
Volume
603
Issue
1
Pages
134–138
Identifiers
PMID: 8095837
Source
Medline
License
Unknown

Abstract

The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N-methyl-D-aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and that the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity.

Report this publication

Statistics

Seen <100 times