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Effects of interferon-gamma and tumor necrosis factor alpha on the expression of the genes encoding aggrecan, biglycan, and decorin core proteins in cultured human chondrocytes.

Authors
  • Dodge, G R
  • Diaz, A
  • Sanz-Rodriguez, C
  • Reginato, A M
  • Jimenez, S A
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Feb 01, 1998
Volume
41
Issue
2
Pages
274–283
Identifiers
PMID: 9485085
Source
Medline
License
Unknown

Abstract

These data demonstrate that 1) the expression of the core protein genes encoding the cartilage proteoglycans aggrecan, biglycan, and decorin is differentially regulated by IFN gamma and TNF alpha; 2) these effects are mediated by transcriptional and posttranscriptional mechanisms; and 3) the combination of the 2 cytokines causes a potent inhibitory effect on the expression of the genes for the core proteins of these 3 proteoglycans, which occurs largely at the transcriptional level. The inhibition of aggrecan, decorin, and biglycan core protein gene expression by the combination of IFN gamma and TNF alpha may contribute to the cartilage destruction that is characteristic of inflammatory joint diseases.

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