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The effects of insulin-like growth factor-1 gene therapy and cell transplantation on rat acute wound model.

Authors
  • Talebpour Amiri, Fereshteh1
  • Fadaei Fathabadi, Fatemeh1
  • Mahmoudi Rad, Mahnaz2
  • Piryae, Abbas1
  • Ghasemi, Azar3
  • Khalilian, Alireza4
  • Yeganeh, Farshid5
  • Mosaffa, Nariman5
  • 1 Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran. , (Iran)
  • 2 Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. , (Iran)
  • 3 Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran. , (Iran)
  • 4 Department of Biostatistics and Social Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran. , (Iran)
  • 5 Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. , (Iran)
Type
Published Article
Journal
Iranian Red Crescent medical journal
Publication Date
Oct 01, 2014
Volume
16
Issue
10
Identifiers
DOI: 10.5812/ircmj.16323
PMID: 25558384
Source
Medline
Keywords
License
Unknown

Abstract

This study indicated that the optimization of gene transfer increases the expression of IGF-1. High concentrations of IGF-1, in combination with cell therapy, have a significant effect on wound healing.

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