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Effects of Initiating or Switching to a Six-Monthly Triptorelin Formulation on Prostate Cancer Patient–Healthcare Interactions and Hospital Resource Use: a Real-World, Retrospective, Non-Interventional Study

Authors
  • Cornford, Philip1
  • Jefferson, Kieran2
  • Cole, Owen3
  • Gilbody, John4
  • 1 Royal Liverpool University Hospitals, Department of Urology, Liverpool, UK , Liverpool (United Kingdom)
  • 2 University Hospitals Coventry and Warwickshire NHS Trust, Urology Department, Coventry, UK , Coventry (United Kingdom)
  • 3 The Medical Specialist Group, Urology Department, St Martin’s, Guernsey , St Martin’s (Guernsey)
  • 4 Ipsen Limited, Medical Department, Slough, UK , Slough (United Kingdom)
Type
Published Article
Journal
Oncology and Therapy
Publisher
Springer Healthcare
Publication Date
Nov 05, 2018
Volume
6
Issue
2
Pages
173–187
Identifiers
DOI: 10.1007/s40487-018-0087-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

IntroductionLuteinising hormone-releasing hormone agonist (LHRHa) injections are currently used in the treatment of advanced prostate cancer, but the frequency of injections may represent a burden to patients and healthcare services. The aim of this study was to collect real-world evidence about clinical and practical outcomes for patients with prostate cancer initiating six-monthly triptorelin, or switching from shorter-acting formulations to six-monthly triptorelin, in hospitals in the DEcapeptyl SERVice Evaluation project.MethodsUp to 2 years of data were collected retrospectively by physicians from records of 88 patients receiving six-monthly triptorelin at three centres. The primary outcome measure was the change in the number of patient–healthcare interactions (patient reviews, prostate-specific antigen (PSA) tests, and LHRHa injections) over a 24-month treatment period.ResultsThis analysis included 47 patients newly initiated on six-monthly triptorelin and 41 who received 12 months of a one- or three-monthly LHRHa before switching to six-monthly triptorelin. After switching to six-monthly triptorelin, there was a statistically significant reduction in patient reviews (46.8%), injections (46.8%), and PSA tests (26.6%; all P < 0.0001). The total number of patient–healthcare interactions was significantly reduced (41.5%; P < 0.0001). Based upon cost of these interactions only, the cost reduction of switching to six-monthly triptorelin was £10,214.85 (£249.14 per patient) over 12 months. At 12 months, median PSA was 1.30 ng/mL (23.50 ng/mL at diagnosis) for newly treated patients and 0.24 ng/mL (0.35 ng/mL at switch) for patients who had switched treatment. No safety issues were identified.ConclusionSwitching from one- or three-monthly LHRHa to six-monthly triptorelin significantly reduced patient–healthcare interactions and associated costs while maintaining PSA control over a 12-month treatment period. This not only translates into healthcare savings but may release men from the restriction of repeated healthcare interactions and thus improve the overall patient experience as the population of long-term prostate cancer survivors continues to increase.FundingIpsen Limited.

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