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Effects of induced tolerance to bacterial lipopolysaccharide on myocardial infarct size in rats.

Authors
  • Eising, G P
  • Mao, L
  • Schmid-Schonbein, G W
  • Engler, R L
  • Ross, J
Type
Published Article
Journal
Cardiovascular research
Publication Date
Jan 01, 1996
Volume
31
Issue
1
Pages
73–81
Identifiers
PMID: 8849591
Source
Medline
License
Unknown

Abstract

LPS desensitization in rats for 1 week prior to coronary occlusion inhibited activation of circulating PMNs 3 days after reperfusion following 45 min of coronary occlusion. LPS also is well-known to induce heat stress proteins and may affect other protective mechanisms. These actions are associated with a significant reduction in myocardial infarct size in LPS-tolerant animals compared to untreated controls.

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