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Effects of indomethacin and prostaglandins on ovulation of goldfish.

Authors
Type
Published Article
Journal
Prostaglandins
Publication Date
Volume
9
Issue
4
Pages
597–607
Identifiers
PMID: 1153811
Source
Medline
License
Unknown

Abstract

A technique is described whereby elevated temperature and HCG injection yield a high percentage of ovulation in gravid goldfish. Indomethacin (10 mug/g; i.p. injection) completely inhibits ovulation if given within 6 hours following HCG (4 IU/g); the unovulated oocytes develop rapidly into corpora atretica. PGE1, PGE2, and PGF2alpha (5 mug/g; i.p. injection) induce ovulation in fish treated with indomethacin and HCG; PGE2 was most effective when given 11 hours after HCG. The results suggest that the ovulatory action of prostaglandins following HCG stimulation is at the level of the ovary and that it is restricted to a period between 7 and 12 hours after the gonadotropin injection.

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