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Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats.

Authors
  • Masuoka, Takayoshi
  • Mikami, Azusa
  • Yasuda, Masa
  • Shinomiya, Kazuaki
  • Kamei, Chiaki
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Dec 08, 2007
Volume
576
Issue
1-3
Pages
77–82
Identifiers
PMID: 17884040
Source
Medline
License
Unknown

Abstract

The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at doses of 10 and 20 mg/kg, and a significant increase was also observed in reference memory errors at a dose of 20 mg/kg. Diphenhydramine and chlorphenilamine at a dose of 20 mg/kg and triprolidine at a dose of 35 mg/kg also caused significant increases in the number of total, reference memory and working memory errors. Promethazine, diphenhydramine and chlorphenilamine, having potent anti-muscarinic receptor properties, increased hippocampal theta power during radial maze performance at a dose of 20 mg/kg. On the other hand, triprolidine, which has weak anti-muscarinic receptor properties compared with other histamine H(1) receptor antagonists, decreased theta power at a dose of 35 mg/kg. These results suggest that anti-muscarinic receptor properties rather than anti-histamine H(1) receptor properties may affect hippocampal theta power during spatial memory deficit induced by promethazine, diphenhydramine and chlorphenilamine.

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