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Effects of the H2-antagonists famotidine and nizatidine and the cytoprotectant misoprostol on human colonic and rat peritoneal mast cells.

Authors
  • Shah, P M
  • Boulos, P B
  • Springall, R
  • Vashisht, R
  • Pearce, F L
Type
Published Article
Journal
Agents and Actions
Publisher
Springer-Verlag
Publication Date
Jun 01, 1994
Volume
41 Spec No
Identifiers
PMID: 7976805
Source
Medline
License
Unknown

Abstract

The H2-antagonists famotidine and nizatidine produced a dose-dependent inhibition of histamine release from human colonic mucosal and muscle mast cells stimulated with anti-IgE. The IC30 values were in the range 0.5-10 microM and the maximum inhibition approached 50%. The compounds showed similar efficacy against rat peritoneal mast cells but were more potent. The cytoprotectant misoprostol had a striking effect on the human colonic mast cells, producing more than 50% inhibition at concentrations of 0.1-1 nM, but was much less active against the rat cells.

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