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Effects of female sex hormones on caffeine-induced epileptiform activity in rats.

Authors
  • Borekci, Bunyamin1
  • Ingec, Metin
  • Yilmaz, Mehmet
  • Kukula, Osman
  • Karaca, Mehmet
  • Hacimuftuoglu, Ahmet
  • Halici, Zekai
  • Suleyman, Halis
  • 1 Faculty of Medicine, Department of Obstetrics and Gynecology, Atatürk University, Erzurum, Turkey. , (Turkey)
Type
Published Article
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Publication Date
May 01, 2010
Volume
26
Issue
5
Pages
366–371
Identifiers
DOI: 10.3109/09513590903511513
PMID: 20063987
Source
Medline
License
Unknown

Abstract

Research on female sex hormones has demonstrated that estrogen aggravates epileptogenesis. Theoretically, this means that the frequency of epileptic attacks should be decreased in epileptic women during menopause. However, although epilepsy attacks are reported to decrease in some women during menopause, they may not change in others. Increases in attack frequency have even been reported during menopause in some epileptic women. This study has investigated the effects of estrogen, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) on caffeine-induced epileptiform activity in rats. Estrogen was found to increase epileptiform activity in a dose-dependent manner via its own receptors. In contrast, progesterone had no effect on epileptiform activity. FSH and LH suppressed epileptiform activity at low doses; however, at high doses they enhanced it. In conclusion, we suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH.

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