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Effects of exercise on the biochemical aging of mammalian myocardium. I. Actomyosin ATPase.

Authors
  • Rockstein, M
  • Chesky, J A
  • Lopez, T
Type
Published Article
Journal
Journal of gerontology
Publication Date
May 01, 1981
Volume
36
Issue
3
Pages
294–297
Identifiers
PMID: 6453150
Source
Medline
License
Unknown

Abstract

Male Fischer 344 rats were subjected to regular forced exercise beginning at weaning and continued until sacrificed at ages ranging from 2 to 18 months. Littermates served as sedentary controls. At all ages examined, the exercised animals had greater heart and lower body weights. Actomyosin was isolated from the myocardium and the ATPase activity of the contractile protein preparation was measured. Only the sedentary animals exhibited an age-related loss in enzyme activity. The physically trained animals had substantially higher ATPase specific activity than the controls at all ages. This difference in ATPase specific activity may be the result of the synthesis of different isozymic forms of myosin or changes in the regulatory proteins of actomyosin (tropomyosin and troponin). It is suggested that lifelong regular exercise may alter the known biochemical changes in the heart muscle that relate to declining cardiac function.

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