Affordable Access

[Effects of Early Enteral Immunonutrition on Postoperative Immune Function and Rehabilitation of Patients with Gastric Cancer and Nutritional Risk].

Authors
  • Peng, Chang-Bing1, 2
  • Li, Wen-Zhong2
  • Xu, Rui1
  • Zhuang, Wen1
  • 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. , (China)
  • 2 Department of Gastrointestinal Surgery, Chengdu 363 Hospital, Chengdu 610041, China. , (China)
Type
Published Article
Journal
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Publication Date
May 01, 2017
Volume
48
Issue
3
Pages
427–430
Identifiers
PMID: 28616919
Source
Medline
Keywords
Language
Chinese
License
Unknown

Abstract

To investigate the effects of early enteral immunonutrition on postoperative immune function and rehabilitation of gastric cancer patients with nutritional risk. New hospitalized patients with gastric cancer were evaluated the nutrient status based on NRS 2002. The patients who scored between 3 to 5 points were randomized into two groups(30 cases for each group), and those in experimental group were given 7-d early postoperative enteral immune nutrition, those in control group were given normal nutrition. The immune indexes (CD3+, CD4+, CD8+ and CD4+/CD8+) and nutritional indexes(transferrin, pre-albumin, albumin) were measured before operation and at the 3rd and 7th day postoperatively. In addition, the first flatus time, gastrointestinal adverse reactions and complications, length of hospital stays were compared between the two groups. The level of CD4+/CD8+ and transferrin, pre-albumin, albumin in experimental group were significantly higher than those in control group at the third and seventh day postoperatively (P<0.05).Compared with the control group, the experimental group had shorter first flatus time after surgery, which were (63.5±7.3) h vs. (72.8±8.6 ) h respectively (P<0.05).There were no statistically difference on pneumonia, anastomosis leakage, severe abdominal distension, inflammatory bowel obstruction and total postoperative hospitalization time between the two groups (P>0.05). Early enteral immunonutrition can effectively promote the recovery of nutritional status and immune function in gastric cancer patients with nutrition risk.

Report this publication

Statistics

Seen <100 times