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The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

Authors
  • Bolevich, Stefani1
  • Draginic, Nevena2
  • Andjic, Marijana2
  • Jeremic, Nevena2
  • Bolevich, Sergey3
  • Litvitskiy, Petr F1
  • Jakovljevic, Vladimir3, 4
  • 1 Department of Pathophysiology, Russian Federation , (Russia)
  • 2 Faculty of Medical Sciences, Department of Pharmacy, Serbia , (Serbia)
  • 3 Department of Human Pathology, Russian Federation , (Russia)
  • 4 Faculty of Medical Sciences, Department of Physiology, Serbia , (Serbia)
Type
Published Article
Journal
Serbian Journal of Experimental and Clinical Research
Publisher
Sciendo
Publication Date
Dec 31, 2019
Volume
20
Issue
4
Pages
301–307
Identifiers
DOI: 10.2478/sjecr-2019-0037
Source
De Gruyter
Keywords
License
Green

Abstract

The aim of the present study was to examine, evaluate and compare the effects of administered dipeptidyl peptidase-4 (DPP4) inhibitors saxagliptin and sitagliptin on lipid status parameters and blood pressure in rats with streptozotocine induced diabetes mellitus type 2. Forty-eight Wistar albino rats were divided randomly into 4 groups: 1. group I: control healthy group; 2. group II: rats with diabetes mellitus type 2; 3. group III: rats with diabetes mellitus type 2+ treated with 0.6 mg/kg of sitagliptin; 4. group IV: rats with diabetes mellitus type 2 treated with 0.45 mg/kg of saxagliptin. The rats from experimental groups were fed with a high-fat diet for 4 weeks and after 6–8 h of starvation received one dose of streptozotocin (STZ) intraperitoneally (25 mg/kg body weight) to induce type 2 diabetes mellitus (T2DM). Animals with fasting glucose above 7 mmol/L and insulin over 6 mmol/L were included in the study as rats with T2DM. Upon completion of the experiments, the blood was collected from the anesthetized animals and serum triglyceride (TG), total cholesterol (TCH), high density lipoprotein (HDL), and low density lipoprotein (LDL) were measured using spectrophotometry and commercial kits. At the beginning of the study and the day before sacrificing animals, the blood pressure and heart rate were measured by a tail-cuff noninvasive method. DPP4 inhibitors, as glucagon-like peptide-1 (GLP-1) agonists, were associated with modest reductions in DBP, LDL-C, TCH, and TGL and significant improvement in HDL, SBP and HR.

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