Affordable Access

deepdyve-link
Publisher Website

Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells.

Authors
  • Lai, Li-hong
  • Wang, Ru-xing
  • Jiang, Wen-ping
  • Yang, Xiang-jun
  • Song, Jian-ping
  • Li, Xiao-rong
  • Tao, Guo
Type
Published Article
Journal
Acta Pharmacologica Sinica
Publisher
Springer Nature
Publication Date
Mar 01, 2009
Volume
30
Issue
3
Pages
314–320
Identifiers
DOI: 10.1038/aps.2009.7
PMID: 19262555
Source
Medline
License
Unknown

Abstract

DHA can activate BK(Ca) channels and block K(V) channels in rat CASMCs, and the EC(50) of DHA for BK(Ca) channels is lower than that for K(V) channels; these findings indicate that the vasorelaxation effects of DHA on vascular smooth muscle cells are mainly due to its activation of BK(Ca) channels.

Report this publication

Statistics

Seen <100 times