We investigated the effects of different exercise intensities on C-reactive protein (CRP), and whether changes in CRP levels correlated with blood lipid levels. Ten men exercised at 25%, 65%, and 85% of their maximum oxygen consumption rates. Participants' blood was analyzed for CRP and blood lipid levels before and after the exercise sessions. Although there was an intensity effect for postexercise high-density lipoprotein levels, there were no significant differences or correlations for postexercise CRP levels or between CRP and lipid levels across the three exercise intensities. In an acute aerobic bout model with isoenergetic expenditures, CRP was not affected by the exercise intensity. Additionally, changes in blood lipid levels might not have been connected to CIRP levels for physically fit participants.