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Effects of DGAVP on verbal memory.

Authors
  • Pietrowsky, R1
  • Fehm-Wolfsdorf, G
  • Born, J
  • Fehm, H L
  • 1 Angewandte Physiologie and Innere Medizin I, Universität Ulm, FRG.
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1988
Volume
9
Issue
6
Pages
1361–1366
Identifiers
PMID: 3247253
Source
Medline
License
Unknown

Abstract

Effects of DGAVP (desglycinamide-arginine-vasopressin, a synthetic vasopressin analog) on verbal memory were investigated in 13 healthy male volunteers. Ten word lists, each consisting of 15 words, were presented to the subjects who had to recall them according to a free recall paradigm. The total number of recalled words was not different between DGAVP and placebo treatment; but DGAVP had an effect on memory performance depending on the serial position of the words. It attenuated the primacy effect and enhanced the recency effect of memory performance. The pattern of changes after DGAVP may be consistent with an effect of the peptide on general arousal. Since the experiment was not designed to test influences of DGAVP on arousal, these considerations remain tentative.

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