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Effects of daidzein and kiwifruit on bone mineral density and equol production in ovariectomised rats.

Authors
  • Tousen, Yuko
  • Wolber, Frances M
  • Chua, Wei-Hang
  • Tadaishi, Miki
  • Ishimi, Yoshiko
  • Kruger, Marlena C
Type
Published Article
Journal
International journal of food sciences and nutrition
Publication Date
May 01, 2014
Volume
65
Issue
3
Pages
360–367
Identifiers
DOI: 10.3109/09637486.2013.858238
PMID: 24251973
Source
Medline
License
Unknown

Abstract

In this study, we investigated the synergistic effects of daidzein (Dz) and kiwifruit on bone and equol production in ovariectomised (OVX) rats. Female Sprague-Dawley rats were randomly assigned to one of five groups: sham operated, OVX control, OVX fed 0.1% Dz-supplemented diet (OVX + Dz), OVX fed 0.1% Dz and green kiwifruit (GRK)-supplemented diet (OVX + Dz + GRK) and OVX fed 0.1% Dz and gold kiwifruit (GOK)-supplemented diet (OVX + Dz + GOK). There were no significant differences in whole body and femur bone mineral density (BMD) among groups at week 8. BMD in the OVX group significantly decreased at week 8; however, BMD in the OVX + Dz + GRK was not significantly different from baseline in the end of the study. However, supplementation with kiwifruit did not affect urinary equol concentrations, urinary ratios of equol to Dz and the composition of caecal microbiota. These results suggest that the combination of Dz and GRK may slightly reduce bone loss caused by oestrogen deficiency but does not affect equol production.

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