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The effects of cysteamine and capsaicin on somatostatin and substance P in medullary nuclei.

Authors
  • Helke, C J
  • Selsky, J H
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1983
Volume
4
Issue
5
Pages
669–672
Identifiers
PMID: 6197700
Source
Medline
License
Unknown

Abstract

Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin content of any of the medullary nuclei assayed while depleting the substance P content of the spinal trigeminal nucleus in the same animals.

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