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Effects of cyproterone acetate on reproductive functions in normal human males.

Authors
Type
Published Article
Journal
Contraception
0010-7824
Publisher
Elsevier
Publication Date
Volume
14
Issue
4
Pages
403–420
Identifiers
PMID: 975826
Source
Medline
Keywords
License
Unknown

Abstract

The effects of cyproterone acetate (CA) on reproductive functions in normal human males were studied. 6 volunteers received 5 or 10 mg CA over a 20-week period. The treatment caused a gradual decrease in the number of spermatozoa and their motility, and an increase in the percentage of nonmotile, abnormal, and immature sperms. There was also a marked inhibition of sperm transport of motile sperm through cervical mucus, as determined by Kremer's test. Semen levels of acid phosphatase, sialic acid, and glycerylphosphorylcholine progressively decreased, though semen levels of fructose were not markedly altered. There were no marked changes in levels of SGOT, SGPT, serum alkaline phosphatase, blood urea, and hematocrit values. The possible mode of action of CA and its potential as a male contraceptive agent are discussed.

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