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The effects of Cuminum cyminum on glycemic parameters: A systematic review and meta-analysis of controlled clinical trials.

Authors
  • Tavakoli-Rouzbehani, Omid Mohammad1
  • Faghfouri, Amir Hossein2
  • Anbari, Maryam1
  • Papi, Shahab3
  • Shojaei, Farid Salimi4
  • Ghaffari, Mehdi5
  • Alizadeh, Mohammad6
  • 1 Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected] , (Iran)
  • 3 Department of Public Health, Faculty of Health, Social Determinants of Health Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. , (Iran)
  • 4 Department of Medical Sciences, Marand Branch, Islamic Azad University, Marand, Iran. , (Iran)
  • 5 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 6 Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Journal of ethnopharmacology
Publication Date
Aug 06, 2021
Pages
114510–114510
Identifiers
DOI: 10.1016/j.jep.2021.114510
PMID: 34371114
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cuminum Cyminum (CC) is a traditional herbal medicine using as an antiseptic, anti-carcinogenic, anti-mutagenic, anti-cancer, anti-hypertensive, anti-inflammatory, and antioxidant. Recently hypoglycemic characteristics of CC have been indicated. We intended to conduct a meta-analysis on the effect of CC supplementation on glycemic parameters in patients with different chronic diseases. PubMed, Embase, Web of Science, and Scopus were searched until May 2021. Random effect model was conducted to perform the meta-analysis. Source of heterogeneity was explored using the meta-regression and subgroup analyses. The Cochrane Collaboration's tool was used to assess the quality of studies. The GRADE approach was used to assess the quality of evidence. Findings of eight studies showed that CC supplementation reduced FBS (SMD = -1.4 mg/dl; 95 % CI: -2.29, -0.51; P = 0.002), HbA1c (SMD = -1.71 %; 95 % CI: -3.24, -0.18; P = 0.028), and HOMA-β (SMD = 0.46; 95 % CI: -0.62, 1.55; P = 0.404) significantly. Also, CC increased QUICKI level (SMD = 0.89; 95 % CI: 0.37, 1.4; P = 0.001. However, no significant effect of CC was observed on insulin (SMD = -0.70 μIU/dl; 95 % CI: -1.84, 0.45; P = 0.234) and HOMA-IR (SMD = 0.46; 95 % CI: -0.62, 1.55; P = 0.404). CC had an improving effect on FBS, HbA1C, HOMA-B, and QUICKI. The effect of CC on amending HOMA-IR was significant after sensitivity analysis. However, the insulin level was not changed significantly. Copyright © 2021. Published by Elsevier B.V.

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