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Effects of COVID-19 on Parkinson's Disease Clinical Features: A Community-Based Case-Control Study.

Authors
  • Cilia, Roberto1
  • Bonvegna, Salvatore1
  • Straccia, Giulia1, 2
  • Andreasi, Nico Golfrè1
  • Elia, Antonio E1
  • Romito, Luigi M1
  • Devigili, Grazia1
  • Cereda, Emanuele3
  • Eleopra, Roberto1
  • 1 Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Parkinson and Movement Disorders Unit, Milan, Italy. , (Italy)
  • 2 Department of Medical Sciences and Advanced Surgery, University of Campania, Naples, Italy. , (Italy)
  • 3 Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. , (Italy)
Type
Published Article
Journal
Movement Disorders
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2020
Volume
35
Issue
8
Pages
1287–1292
Identifiers
DOI: 10.1002/mds.28170
PMID: 32449528
Source
Medline
Language
English
License
Unknown

Abstract

The impact of coronavirus disease 2019 (COVID-19) on clinical features of Parkinson's disease (PD) has been poorly characterized so far. Of 141 PD patients resident in Lombardy, we found 12 COVID-19 cases (8.5%), whose mean age and disease duration (65.5 and 6.3 years, respectively) were similar to controls. Changes in clinical features in the period January 2020 to April 2020 were compared with those of 36 PD controls matched for sex, age, and disease duration using the clinical impression of severity index for PD, the Movement Disorders Society Unified PD Rating Scale Parts II and IV, and the nonmotor symptoms scale. Motor and nonmotor symptoms significantly worsened in the COVID-19 group, requiring therapy adjustment in one third of cases. Clinical deterioration was explained by both infection-related mechanisms and impaired pharmacokinetics of dopaminergic therapy. Urinary issues and fatigue were the most prominent nonmotor issues. Cognitive functions were marginally involved, whereas none experienced autonomic failure. © 2020 International Parkinson and Movement Disorder Society. © 2020 International Parkinson and Movement Disorder Society.

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