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Effects of controllable and uncotrollable stresses on the receptor binding of dexamethasone in the hypophysis and hippocampus of rats with different behavior strategies

Authors
  • Ordyan, N. É.
  • Zhukov, D. A.
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Kluwer Academic Publishers-Plenum Publishers
Publication Date
Jan 01, 1998
Volume
28
Issue
1
Pages
22–25
Identifiers
DOI: 10.1007/BF02461907
Source
Springer Nature
Keywords
License
Yellow

Abstract

The effects of controllable and uncontrollable stress on the receptor binding of dexamethasone in the hypophysis and hippocampus were studied in KHA and KLA rats, lines selected for the ability to development of active escape. Presentation of the controllable stimulus led to a significant reduction in receptor binding of dexamethasone in the hippocampus with significant changes in the plasma corticosterone concentration and receptor binding in the hypophysis. KLA rats were sensitive both to the controllable and the uncontrollable stresses, with increases in plasma corticosterone and receptor binding of dexamethasone in the hypophysis. It is concluded that receptor binding of dexamethasone in the hippocampus and hypophysis depend not only on the behavioral strategy of the animal, but also on the possibility of controlling the situation.

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