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Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study.

Authors
  • Lopes, Antonio Carlos1
  • Greenberg, Benjamin D
  • Norén, Georg
  • Canteras, Miguel Montes
  • Busatto, Geraldo F
  • de Mathis, Maria Eugênia
  • Taub, Anita
  • D'Alcante, Carina Chaubet
  • Hoexter, Marcelo Queiroz
  • Gouvea, Fernando Sauerbronn
  • Cecconi, Janaína Philippi
  • Gentil, André F
  • Ferrão, Ygor Arzeno
  • Fuentes, Daniel
  • de Castro, Cláudio Campi
  • Leite, Cláudia C
  • Salvajoli, João Victor
  • Duran, Fábio L S
  • Rasmussen, Steven
  • Miguel, Eurípedes Constantino
  • 1 Obsessive Compulsive Spectrum Disorders Program (PROTOC), Department of Psychiatry, University of São Paulo School of Medicine, R. Dr. Ovídio Pires de Campos, 785, 3 degrees andar, sala 9, São Paulo, SP 01060-970, Brazil. [email protected]
Type
Published Article
Journal
The Journal of neuropsychiatry and clinical neurosciences
Publication Date
2009
Volume
21
Issue
4
Pages
381–392
Identifiers
DOI: 10.1176/appi.neuropsych.21.4.381
PMID: 19996246
Source
Medline
License
Unknown

Abstract

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.

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