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Effects of a cluster-randomized school-based prevention program on physical activity and microvascular function (JuvenTUM 3).

Authors
  • Siegrist, Monika1
  • Hanssen, Henner2
  • Lammel, Christoph3
  • Haller, Bernhard4
  • Koch, Anna-Maria3
  • Stemp, Pia3
  • Dandl, Elke3
  • Liestak, Roberta3
  • Parhofer, Klaus G5
  • Vogeser, Michael6
  • Halle, Martin7
  • 1 Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany. Electronic address: [email protected] , (Germany)
  • 2 Department of Sport, Exercise and Health, Division of Sports and Exercise Medicine, University of Basel, Switzerland. , (Switzerland)
  • 3 Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany. , (Germany)
  • 4 Institute of Medical Informatics, Statistics and Epidemiology, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany. , (Germany)
  • 5 Department of Internal Medicine II, University of Munich, Großhadern Campus, Munich, Germany. , (Germany)
  • 6 Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany. , (Germany)
  • 7 Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany. , (Germany)
Type
Published Article
Journal
Atherosclerosis
Publication Date
Nov 01, 2018
Volume
278
Pages
73–81
Identifiers
DOI: 10.1016/j.atherosclerosis.2018.09.003
PMID: 30261471
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

It is unknown whether a school-based prevention program has the potential to improve microvascular health in children. This study investigates the impact of the school-based lifestyle intervention program JuvenTUM 3 on physical activity, physical fitness, serum biomarkers and microvascular function. We studied 434 children (10-11 years) in a cluster-randomized setting (8 intervention schools, IG; 7 control schools, CG) over 18 months. The school-based prevention program included weekly lifestyle lessons for children with the aim to increase physical activity in and outside of school, physical fitness as well as health behavior. Anthropometric measurements and blood sampling were conducted using standard protocols, physical activity by use of a questionnaire and physical fitness by a 6-item-test battery. Central retinal arteriolar (CRAE) and venular (CRVE) vessel diameters as early marker of vascular dysfunction, as well as the arteriolar-to-venular diameter ratio (AVR), were investigated with a non-mydriatic vessel analyser. School-based physical activity increased in 41% of children in IG (19% in CG, p = 0.038). Improvements in vascular parameters were observed for AVR (increase in 83% of children in IG versus 50% in CG; p < 0.001) and for CRVE (43% of children with retinal venular widening in IG versus 58% in CG, p = 0.019). These vascular improvements were also seen in overweight children for CRAE (p = 0.021) and AVR (p < 0.001). The school-based prevention program JuvenTUM 3 increased physical activity at school inducing favourable effects on retinal microvasculature function. These findings underline the importance of early lifestyle interventions in children for primary prevention of cardiovascular disease. Copyright © 2018 Elsevier B.V. All rights reserved.

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