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The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men.

  • Safarzade, Alireza1, 2
  • Alizadeh, Hamid1
  • Bastani, Zainab1
  • 1 Department of Exercise Physiology, Faculty of Sport Sciences, Islamic Azad University of Sari Branch, Sari, Mazandaran, Iran. , (Iran)
  • 2 Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran. , (Iran)
Published Article
Hormone molecular biology and clinical investigation
Publication Date
Mar 09, 2020
DOI: 10.1515/hmbci-2019-0050
PMID: 32146440


Background Progranulin (PGRN) is implicated in obesity and insulin resistance (IR). The aim of this study was to evaluate the effects of 8 weeks of circuit resistance training (CRT) on plasma PGRN, IR and body composition in obese men. Materials and methods Twenty-eight healthy obese men [age: 36 ± 7.7 years, body weight (BW): 96.4 ± 15.6 kg, body mass index (BMI): 32.4 ± 4.5 kg/m2] completed the study. Subjects were randomly assigned to two groups of control and training. Subjects in the training group underwent training for 8 weeks, 3 times a week. Blood samples and anthropometric characteristics were taken before the commencement of the exercise protocol and 72 h after the last training session. The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure IR. Results BW, BF%, BMI, waist-hip ratio (WHR), HOMA-IR and plasma PGRN levels except lean body mass (LBM) were significantly reduced in the training group (p < 0.05). Additionally, except for LBM, subjects in the training group had significantly decreased BW, BF%, BMI, WHR, HOMA-IR and plasma PGRN levels compared to changes in those in the control group (p < 0.05). Significant correlations were found between the changes in plasma PGRN and the changes in insulin, HOMA-IR and BMI (p < 0.05). Conclusions The findings showed that 8 weeks of CRT improved body composition and IR which were accompanied by reduced plasma PGRN levels. This study suggests that CRT has the potential for obese individuals to counteract obesity-associated health impairments.

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