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Effects of chronic opioid antagonism on gonadotrophin and ovarian sex steroid secretion during the luteal phase.

Authors
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Volume
49
Issue
3
Pages
343–351
Identifiers
PMID: 9861326
Source
Medline

Abstract

Chronic opioid antagonism with naltrexone did not disrupt the temporal organization or endocrine characteristics of the luteal phase. In particular, prolonged opioid blockade did not change LH secretory patterns. The functional and temporal links between LH inputs and sex steroid release from the mature corpus luteum remained unaffected by prolonged opioid antagonism. In contrast to the effects of short-term opioid blockade on LH pulsatile release during the luteal phase, the effects of chronic opioid antagonism on LH release may be transient and may not persist throughout the entire luteal phase, suggesting desensitization of the opiate receptors.

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