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Effects of calcium and temperature on tension in isolated canine coronary artery.

Authors
  • Yoshida, K
  • Fujii, Y
  • Ina, H
  • Fujioka, S
  • Maseki, T
  • Abe, T
  • Tokuno, H
  • Tomita, T
Type
Published Article
Journal
Journal of anesthesia
Publication Date
Apr 01, 1991
Volume
5
Issue
2
Pages
172–176
Identifiers
PMID: 15278652
Source
Medline
License
Unknown

Abstract

The effects of calcium and temperature on the tension of isolated canine coronary arterial strips were studied. In 20 mEq. l(-1) K solution, the tension was significantly increased from 0 mg with 0 mEq. l(-1) Ca to 33 +/- 18 mg with 0.2 mEq. l(-1) Ca at 37 degrees C, from -40 +/- 18 mg with 0 mEq. l(-1) Ca to -17 +/- 11 mg with 0.2 mEq. l(-1) Ca at 30 degrees C, from -77 +/- 19 mg with 0 mEq. l(-1) Ca to -52 +/- 17 mEq. l(-1) with 1 mEq. l(-1) Ca at 25 degrees C, from -88 +/- 13 mg with 0 mEq. l(-1) Ca to -41 +/- 18 mg with 2 mEq. l(-1) Ca at 20 degrees C, from -125 +/- 16 mg with 0 mEq. l(-1) Ca to -116 +/- 13 mg with 2 mEq. l(-1) Ca at 15 degrees C. Ca higher than 0.2 mEq. l(-1) produced a dose-dependent increase in tension between 37 degrees C and 15 degrees C. In spite of the presence of 4 mEq. l(-1) Ca, the development of tension was strongly supressed by lowering the temperature below 20 degrees C, and completely inhibited at 10 degrees C. The rate of a decrease in tension caused by cooling was about 5.5 mg. degrees C(-1). This study demonstrated that Ca(2+) produced a dose-dependent increase in tension in high-K solution, which was suppressed as the temperature was lowered.

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