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The effects of bumetanide on human umbilical artery contractions.

Authors
  • Dayioglu, Emel
  • Buharalioglu, C Kemal
  • Saracoglu, Ferit
  • Akar, Fatma
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
Apr 01, 2007
Volume
14
Issue
3
Pages
246–252
Identifiers
PMID: 17636238
Source
Medline
License
Unknown

Abstract

The authors investigate the effect of bumetan ide, an inhibitor of NKCC1 and a loop diuretic, on the tone of human umbilical artery (HUA). Rings of HUA (n = 35) from vaginal deliveries were suspended for isometric tension recordings in organ baths. Cumulative concentration-response curves to serotonin, histamine, and KCl were performed in the absence (control) or in the presence of bumetanide. The relaxant effect of bumetanide was also evaluated in serotonin- and histamine-induced contractions. Bumetanide inhibited HUA tone in serotonin- and histamine-induced contractions with significant changes in the potency (pD(2)) and maximum contractile response (E(max)) values. However, only pD( 2) values for KCl-induced contraction significantly changed in the presence of bumetanide. Bumetanide caused concentration-dependent and sustained relaxations in serotonin-induced contraction; however, there was refractoriness in histamine-induced contraction. These findings raise the possibility that NKCC1 may play a role in the regulation of the umbilical artery tone.

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