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Effects of budesonide on P-glycoprotein expression in intestinal cell lines.

Authors
  • Maier, A
  • Zimmermann, C
  • Beglinger, C
  • Drewe, J
  • Gutmann, H
Type
Published Article
Journal
British journal of pharmacology
Publication Date
Feb 01, 2007
Volume
150
Issue
3
Pages
361–368
Identifiers
PMID: 17179942
Source
Medline
License
Unknown

Abstract

Budesonide has the potential to influence MDR1 expression in vitro. In LS180 cells, the induction of MDR1 by budesonide probably is mediated via PXR. The mechanism of the down-regulation in Caco-2 cells still remains unclear, but GR does not seem to be involved. Further studies are required to evaluate how budesonide alters P-gp expression in vivo.

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