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The effects of Arvin and surgery on red cell filterability.

Authors
  • Ernst, E
  • Dormandy, J
Type
Published Article
Journal
Scandinavian journal of clinical and laboratory investigation. Supplementum
Publication Date
Jan 01, 1981
Volume
156
Pages
317–319
Identifiers
PMID: 6948396
Source
Medline
License
Unknown

Abstract

Arovin (ancrod) treatment is generally recognized to lower fibrinogen levels and is sometimes used to decrease plasma and whole blood viscosity. The fall in fibrinogen is accompanied by a rise in fibrinogen degradation products (FDP), but none of the other clotting factors is affected. This study shows that patients undergoing surgery with subsequent Arvin treatment decrease their red cell filterability (RCF), and that this drop cannot be explained by either the surgical intervention, a direct effect of Arvin on the red cells, or the lowered fibrinogen levels. However the decrease of RCF does correlate with the rise in FDP.

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