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Effects of Arsenic Trioxide on Minor Progressive High-Grade Osteosarcoma of the Extremities Metastatic to the Lung: Results of 39 Patients Treated in a Single Institution.

Authors
  • Xie, Lu1
  • Guo, Wei1
  • Tang, Xiaodong1
  • Yang, Yi1
  • Xu, Jie1
  • 1 Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China. , (China)
Type
Published Article
Journal
Case reports in oncology
Publication Date
Jan 01, 2016
Volume
9
Issue
3
Pages
610–628
Identifiers
PMID: 27920692
Source
Medline
Keywords
License
Unknown

Abstract

Patients who mildly progressed after first-line chemotherapy were administered arsenic trioxide (ATO) 5-10 mg intravenously daily. Thirty-nine patients were finally enrolled in the study, of whom 19 patients received first-line chemotherapy with ATO infusion while 20 patients did not. Progression-free survival at 4 months was 89.2 and 62.7% (p = 0.043) for the ATO group and the control group, respectively, while the 2-year overall survival was 61 and 16.4% (p = 0.032).

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