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Effects of arginine residue introduction upon interaction and complexation behavior of peptide ribonucleic acids (PRNAs) with RNA: synthesis and properties of alpha-containing arginine.

Authors
  • Wada, Takehiko
  • Sawa, Nobuya
  • Sato, Hirofumi
  • Futaki, Shiroh
  • Inoue, Yoshihisa
Type
Published Article
Journal
Nucleic acids symposium series (2004)
Publication Date
Jan 01, 2008
Issue
52
Pages
673–674
Identifiers
DOI: 10.1093/nass/nrn340
PMID: 18776559
Source
Medline
License
Unknown

Abstract

A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These alpha-PRNA form stable sequence-specific complex with the complementary RNA.

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