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Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes.

Authors
  • Tung, Jayne T
  • Venta, Patrick J
  • Eberhart, Susan W
  • Yuzbasiyan-Gurkan, Vilma
  • Alexander, Lee
  • Caron, John P
Type
Published Article
Journal
American Journal of Veterinary Research
Publisher
American Veterinary Medical Association
Publication Date
Aug 01, 2002
Volume
63
Issue
8
Pages
1134–1139
Identifiers
PMID: 12171167
Source
Medline
License
Unknown

Abstract

Prostaglandin E2 is considered to be an important mediator in the pathophysiologic processes of arthritis, and cultured chondrocytes respond to interleukin-1 with enhanced expression and activity of COX-2. Palliative relief in affected horses is probably attributable, in part, to inhibition of PGE2 synthesis; however, analysis of these data suggests that of the 4 compounds tested, only DEX affects pretranslational regulation of the COX-2 gene in cultured equine chondrocytes.

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