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Effects of aluminum chloride on serum proteins, bilirubin, and hepatic trace elements in chickens.

Authors
  • Wang, Ben1
  • Zhu, Yanzhu2
  • Zhang, Hongling1
  • Liu, Liming1
  • Li, Guojiang1
  • Song, Yongli1
  • Li, Yanfei3
  • 1 College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China. , (China)
  • 2 Institute of Special Animal and Plant Sciences of Chinese Academy of Agricultural Sciences, Changchun, China. , (China)
  • 3 College of Veterinary Medicine, Northeast Agricultural University, Harbin, China [email protected] , (China)
Type
Published Article
Journal
Toxicology and Industrial Health
Publisher
SAGE Publications
Publication Date
September 2016
Volume
32
Issue
9
Pages
1693–1699
Identifiers
DOI: 10.1177/0748233715578035
PMID: 25896954
Source
Medline
Keywords
License
Unknown

Abstract

The aim of this study was to reveal the effects of aluminum chloride (AlCl3) on the hepatic metabolism function and trace elements' distribution. Two hundred healthy male chickens (1 day old) were intraperitoneally administered with AlCl3 (0, 18.31, 27.47, and 36.62 mg kg(-1) day(-1) of Al(3+)) consecutively for 3 days. Then the chickens were allowed to rest for 1 day. The cycle lasted four days. The cycle was repeated 15 times (60 days). The contents of serum total protein (TP), albumin (ALB), total bilirubin (TBI), direct bilirubin (DBI), hepatic aluminum (Al), copper (Cu), iron (Fe), and zinc (Zn) were examined. The results showed that the contents of serum TP and ALB and hepatic Fe and Zn decreased and the contents of serum TBI and DBI and hepatic Al and Cu increased in the chickens with AlCl3 This indicates that chronic administration of AlCl3 impairs the hepatic metabolism function and disorders the hepatic trace elements' distribution.

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