Affordable Access

Publisher Website

The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms.

  • Wang, San-Yu1
  • Lin, I-Mei2
  • Fan, Sheng-Yu3
  • Tsai, Yu-Che1
  • Yen, Cheng-Fang4
  • Yeh, Yi-Chun4
  • Huang, Mei-Feng4
  • Lee, Yu5
  • Chiu, Nien-Mu5
  • Hung, Chi-Fa5
  • Wang, Peng-Wei4
  • Liu, Tai-Ling4
  • Lin, Huang-Chi4
  • 1 Department of Psychology, College of Humanities and Social Sciences, Kaohsiung Medical University, Taiwan. , (Taiwan)
  • 2 Department of Psychology, College of Humanities and Social Sciences, Kaohsiung Medical University, Taiwan; Pervasive Artificial Intelligence Research (PAIR) Labs, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Taiwan. Electronic address: [email protected] , (Taiwan)
  • 3 Institute of Gerontology, College of Medicine, National Cheng Kung University, Taiwan. , (Taiwan)
  • 4 Department of Psychiatry, Kaohsiung Medical University Hospital, Taiwan; Graduate Institute of Medicine, and Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. , (Taiwan)
  • 5 Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. , (Taiwan)
Published Article
Journal of affective disorders
Publication Date
Oct 01, 2019
DOI: 10.1016/j.jad.2019.07.026
PMID: 31302517


Alpha-asymmetry neurofeedback (ALAY) was applied to patients with major depressive disorder (MDD) based on the theory of frontal alpha asymmetry. Neurophysiological studies have found a higher high-beta activity of electroencephalography (EEG) at the posterior cortex among patients with comorbid MDD and anxiety symptoms. The present study examined the effects of ALAY and high-beta down-training (Beta) neurofeedback in symptoms of depression and anxiety and EEG parameters. Eighty-seven patients with comorbid MDD and anxiety symptoms were allocated to the ALAY, Beta, or control groups. Both neurofeedback groups received ten-session neurofeedback. All participants completed the Beck Depression Inventory II (BDI-II), Beck Anxiety Inventory (BAI), and five minutes resting EEG recording at pre-test and post-test. EEG raw signals were transformed into an A1 score [log (F4 alpha) - log (F3 alpha)], P3 and P4 high-beta power. BDI-II and BAI scores decreased at post-test in both ALAY and Beta groups, but no significant difference between the two groups. No significant interaction effect in A1 score at pre-test and post-test between the ALAY, Beta, and control groups. The P3 high-beta was significantly decreased in the Beta group, an increase in the control group, and no change in the ALAY group at post-test compared to the pre-test. Both neurofeedback groups decreased symptoms of depression and anxiety. The Beta group was more effective in decreasing high-beta power at the parietal cortex compared to other groups. This non-invasive psychological intervention can be used in the future for patients with comorbid MDD and anxiety symptoms. Copyright © 2019 Elsevier B.V. All rights reserved.

Report this publication


Seen <100 times