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Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice.

Authors
  • Wang, Jin-Song
  • Liu, Xia
  • Xue, Zhen-Yi
  • Alderman, Lee
  • Tilan, Justin U
  • Adenika, Remi
  • Epstein, Stephen E
  • Burnett, Mary Susan
Type
Published Article
Journal
Chinese medical journal
Publication Date
Apr 01, 2011
Volume
124
Issue
7
Pages
1075–1081
Identifiers
PMID: 21542971
Source
Medline
License
Unknown

Abstract

Our results indicate that a complex array of defects occur with aging that interfere with optimal neovascularization. These include potential impaired mobilization of progenitor cells to ischemic tissue, decreased levels of eNOS and VEGF and delayed responses to ischemia.

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