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Effects of aging on human skin innervation.

Authors
  • Chang, Yang-Chyuan
  • Lin, Whei-Min
  • Hsieh, Sung-Tsang
Type
Published Article
Journal
Neuroreport
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 19, 2004
Volume
15
Issue
1
Pages
149–153
Identifiers
PMID: 15106848
Source
Medline
License
Unknown

Abstract

To understand the effect of aging on human skin innervation, we investigated intraepidermal nerve fiber (IENF) density of skin biopsies. IENF densities of the distal leg were lower in elderly (> or = 60 years of age) than in young adults (19-39 years of age; 7.80 +/- 0.79 vs 13.55 +/- 0.85 fibers/mm, p < 0.01). A similar trend was also observed in the distal forearm (11.67 +/- 1.55 vs 19.39 +/- 1.60 fibers/ mm, p < 0.001). IENF densities were negatively correlated with age according to multiple linear regression analysis on the entire study population (age range: 19-78 years) with standardized coefficients of -0.462 (p < 0.001) in the distal leg and -0.335 (p = 0.005) in the distal forearm. These findings suggest a significant reduction in IENF densities with age.

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