Elderly females had a lower mean lanoteplase CL(t) than elderly males and young females. However, no difference was observed between young and elderly females for the AUC/dose of PPAA. In addition, there were no age-related or gender-related differences observed in the other pharmacodynamic parameters measured.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21545481