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The effects of age and gender on the pharmacokinetics and pharmacodynamics in healthy subjects of the plasminogen activator, lanoteplase.

Authors
  • Vachharajani, Nimish N
  • Raymond, Ralph H
  • Shyu, Wen-Chyi
  • Stouffer, Bruce C
  • Boulton, David W
Type
Published Article
Journal
British Journal of Clinical Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2011
Volume
72
Issue
5
Pages
775–786
Identifiers
DOI: 10.1111/j.1365-2125.2011.04003.x
PMID: 21545481
Source
Medline
License
Unknown

Abstract

Elderly females had a lower mean lanoteplase CL(t) than elderly males and young females. However, no difference was observed between young and elderly females for the AUC/dose of PPAA. In addition, there were no age-related or gender-related differences observed in the other pharmacodynamic parameters measured.

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