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Effects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats.

Authors
  • Bozdogan, Omer1
  • Ekerbicer, Nuran
  • Suveren, Eylem
  • Bikmaz, Sevda P
  • 1 Department of Biology, Faculty of Science and Literature, Abant Izzet Baysal University, Bolu;
Type
Published Article
Journal
Experimental and clinical cardiology
Publication Date
Jan 01, 2002
Volume
7
Issue
1
Pages
20–24
Identifiers
PMID: 19644574
Source
Medline
Keywords
License
Unknown

Abstract

A short episode of ischemia induced by coronary artery occlusion can precondition the myocardium against arrhythmia. The factors that have the potential to protect the myocardium from subsequent ischemia and reperfusion are controversial. In this study, the preconditioning-like effects of adrenaline were investigated in both anesthetized and conscious rats. Adrenaline 0.1 and 0.5 mg/kg or saline was administered 10 min before coronary occlusion in conscious and anesthetized rats. The 0.5 mg/kg dose of adrenaline decreased the total duration of arrhythmia in both models. The incidence of ventricular fibrillation decreased and survival rate increased only in conscious rats administered 0.5 mg/kg adrenaline. As a result, it is suggested that exogenous administration of adrenaline before coronary ligation may precondition and protect the heart against arrhythmia.

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