Affordable Access

The effects of acute-phase inducers and dimethyl sulphoxide on delta-aminolaevulinate synthase activity in human HepG2 hepatoma cells.

Authors
Type
Published Article
Journal
The Biochemical journal
Publication Date
Volume
259
Issue
2
Pages
605–607
Identifiers
PMID: 2541694
Source
Medline
License
Unknown

Abstract

The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant increase in ALA synthase activity. Interleukin-6 increased ALA synthase activity only slightly, but it substantially potentiated the induction of ALA synthase by Me2SO. These data suggest that ALA synthase activity in liver is altered during acute-phase reactions.

Statistics

Seen <100 times