Phytoestrogens has recently been claimed to positively influence menopausal discomforts, including hot flashes. However, little is known about the influence of phytoestrogens on core body temperature during estrogen fluctuation at menopause. With many published findings that phytoestrogens could relieve menopausal complaints, the present review was aimed at assessing the effects of phytoestrogens on thermoregulatory mechanism during menopausal transition. Thephytoestrogens of interest in relation to human health include isoflavones, lignans, coumestans and stilbenes, which are widely distributed within nature. The molecular mechanisms underlying hot flashes are complex. Estrogen fluctuations cause hypothalamic thermoregulatory centre dysfunction which lead to hot flashes during menopause. The effects of phytoestrogens on these mechanisms may help explain the beneficial effects of phytoestrogens for alleviating hot flashes and other menopausal discomforts.