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The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms during Menopausal Transition: Thermoregulatory Mechanism.

Authors
  • Hairi, Haryati Ahmad1
  • Shuid, Ahmad Nazrun2
  • Ibrahim, Nurul Izzah3
  • Jamal, Jamia Azdina1
  • Mohamed, Norazlina1
  • Mohamed, Isa Naina1
  • 1 Universiti Kebangsaan Kuala Lumpur. Malaysia. , (Malaysia)
  • 2 Department of Pharmacology, Faculty of Medicine, Preclinical Building, Universiti Kebangsaan Malaysia, JalanYaacobLatiff, Bandar TunRazak, Cheras, 56000 Kuala Lumpur. Malaysia. , (Malaysia)
  • 3 Lincoln University College Selangor. Malaysia. , (Malaysia)
Type
Published Article
Journal
Current drug targets
Publication Date
Aug 16, 2017
Identifiers
DOI: 10.2174/1389450118666170816123740
PMID: 28814228
Source
Medline
Keywords
License
Unknown

Abstract

Phytoestrogens has recently been claimed to positively influence menopausal discomforts, including hot flashes. However, little is known about the influence of phytoestrogens on core body temperature during estrogen fluctuation at menopause. With many published findings that phytoestrogens could relieve menopausal complaints, the present review was aimed at assessing the effects of phytoestrogens on thermoregulatory mechanism during menopausal transition. Thephytoestrogens of interest in relation to human health include isoflavones, lignans, coumestans and stilbenes, which are widely distributed within nature. The molecular mechanisms underlying hot flashes are complex. Estrogen fluctuations cause hypothalamic thermoregulatory centre dysfunction which lead to hot flashes during menopause. The effects of phytoestrogens on these mechanisms may help explain the beneficial effects of phytoestrogens for alleviating hot flashes and other menopausal discomforts.

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